A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread.
The mechanisms of epileptic discharge generation and spread are not yet fully known. A recently proposed simple biophysical model of interictal and ictal discharges, Epileptor-2, reproduces well the main features of neuronal excitation and ionic dynamics during discharge generation. In order to dist...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0230787 |
| _version_ | 1818678027083579392 |
|---|---|
| author | Anton V Chizhov Aleksei E Sanin |
| author_facet | Anton V Chizhov Aleksei E Sanin |
| author_sort | Anton V Chizhov |
| collection | DOAJ |
| description | The mechanisms of epileptic discharge generation and spread are not yet fully known. A recently proposed simple biophysical model of interictal and ictal discharges, Epileptor-2, reproduces well the main features of neuronal excitation and ionic dynamics during discharge generation. In order to distinguish between two hypothesized mechanisms of discharge propagation, we extend the model to the case of two-dimensional propagation along the cortical neural tissue. The first mechanism is based on extracellular potassium diffusion, and the second is the propagation of spikes and postsynaptic signals along axons and dendrites. Our simulations show that potassium diffusion is too slow to reproduce an experimentally observed speed of ictal wavefront propagation (tenths of mm/s). By contrast, the synaptic mechanism predicts well the speed and synchronization of the pre-ictal bursts before the ictal front and the afterdischarges in the ictal core. Though this fact diminishes the role of diffusion and electrodiffusion, the model nevertheless highlights the role of potassium extrusion during neuronal excitation, which provides a positive feedback that changes at the ictal wavefront the balance of excitation versus inhibition in favor of excitation. This finding may help to find a target for a treatment to prevent seizure propagation. |
| first_indexed | 2024-12-17T09:08:44Z |
| format | Article |
| id | doaj.art-66cff2edfcfb4793bdf1f9d8ad05b5e1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:08:44Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-66cff2edfcfb4793bdf1f9d8ad05b5e12022-12-21T21:55:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023078710.1371/journal.pone.0230787A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread.Anton V ChizhovAleksei E SaninThe mechanisms of epileptic discharge generation and spread are not yet fully known. A recently proposed simple biophysical model of interictal and ictal discharges, Epileptor-2, reproduces well the main features of neuronal excitation and ionic dynamics during discharge generation. In order to distinguish between two hypothesized mechanisms of discharge propagation, we extend the model to the case of two-dimensional propagation along the cortical neural tissue. The first mechanism is based on extracellular potassium diffusion, and the second is the propagation of spikes and postsynaptic signals along axons and dendrites. Our simulations show that potassium diffusion is too slow to reproduce an experimentally observed speed of ictal wavefront propagation (tenths of mm/s). By contrast, the synaptic mechanism predicts well the speed and synchronization of the pre-ictal bursts before the ictal front and the afterdischarges in the ictal core. Though this fact diminishes the role of diffusion and electrodiffusion, the model nevertheless highlights the role of potassium extrusion during neuronal excitation, which provides a positive feedback that changes at the ictal wavefront the balance of excitation versus inhibition in favor of excitation. This finding may help to find a target for a treatment to prevent seizure propagation.https://doi.org/10.1371/journal.pone.0230787 |
| spellingShingle | Anton V Chizhov Aleksei E Sanin A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread. PLoS ONE |
| title | A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread. |
| title_full | A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread. |
| title_fullStr | A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread. |
| title_full_unstemmed | A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread. |
| title_short | A simple model of epileptic seizure propagation: Potassium diffusion versus axo-dendritic spread. |
| title_sort | simple model of epileptic seizure propagation potassium diffusion versus axo dendritic spread |
| url | https://doi.org/10.1371/journal.pone.0230787 |
| work_keys_str_mv | AT antonvchizhov asimplemodelofepilepticseizurepropagationpotassiumdiffusionversusaxodendriticspread AT alekseiesanin asimplemodelofepilepticseizurepropagationpotassiumdiffusionversusaxodendriticspread AT antonvchizhov simplemodelofepilepticseizurepropagationpotassiumdiffusionversusaxodendriticspread AT alekseiesanin simplemodelofepilepticseizurepropagationpotassiumdiffusionversusaxodendriticspread |