Combined Analysis of COX-2 and p53 Expressions Reveals Synergistic Inverse Correlations with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer

Combined Analysis of COX-2 and p53 Expressions Reveals Synergistic Inverse Correlations with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer

Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability—high (MSI-H) and CpG island methylator phenotype (CIMP), characterized by extensive promoter methylation, is associated with MSI-H. However, no studies have...

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Bibliographic Details
Main Authors: Shuji Ogino, Mohan Brahmandam, Takako Kawasaki, Gregory J. Kirkner, Massimo Loda, Charles S. Fuchs
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colon cancer
cyclooxygenase-2
DNA methylation
MethyLight
TP53
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860680028X

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http://www.sciencedirect.com/science/article/pii/S147655860680028X

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