Methylation of p16 ink4a promoter is independent of human papillomavirus DNA physical state: a comparison between cervical pre-neoplastic and neoplastic samples

BACKGROUND Epigenetic modifications in host cells, like p16 ink4a methylation, have been considered as putative complementary mechanisms for cancer development. Because only a small proportion of infected women develop cervical cancer, other factors might be involved in carcinogenesis, either indep...

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Bibliographic Details
Main Authors: Fernanda Nahoum Carestiato, Sergio Menezes Amaro-Filho, Miguel Angelo Martins Moreira, Silvia Maria Baeta Cavalcanti
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2018-12-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100301&lng=en&tlng=en