Simultaneous regression and classification for drug sensitivity prediction using an advanced random forest method

Abstract Machine learning methods trained on cancer cell line panels are intensively studied for the prediction of optimal anti-cancer therapies. While classification approaches distinguish effective from ineffective drugs, regression approaches aim to quantify the degree of drug effectiveness. Howe...

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Bibliographic Details
Main Authors: Kerstin Lenhof, Lea Eckhart, Nico Gerstner, Tim Kehl, Hans-Peter Lenhof
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17609-x