Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

Summary: Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as well as in numerous immune-mediated disorders. Histone citrullination by the enzyme peptidylarginine deiminase 4 (PAD4) and the cons...

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Bibliographic Details
Main Authors: Valentina Poli, Victor Pui-Yan Ma, Marco Di Gioia, Achille Broggi, Mehdi Benamar, Qian Chen, Ralph Mazitschek, Stephen J. Haggarty, Talal A. Chatila, Jeffrey M. Karp, Ivan Zanoni
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Molecular biology
Immunology
Cell biology
Functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012256

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http://www.sciencedirect.com/science/article/pii/S2589004221012256

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