Preparation of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal Efficacy against Superficial Mycosis

Preparation of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal Efficacy against Superficial Mycosis

In this study, a stable and highly skin-permeable topical delivery system for itraconazole (ITZ) was designed to provide effective treatment against superficial mycosis. Herein, ITZ was incorporated into a solution composed of ethanol, benzyl alcohol, hydrochloric acid, Transcutol P, and cyclomethic...

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Bibliographic Details
Main Authors: Laxman Subedi, Seung-Yub Song, Saurav Kumar Jha, Sung-Ho Lee, Rudra Pangeni, Kyo-Tan Koo, Beum Joon Kim, Seung-Sik Cho, Jin Woo Park
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
itraconazole
topical solution
superficial mycosis
skin penetration
nail infiltration
antifungal activity
Online Access:https://www.mdpi.com/1999-4923/13/5/622

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https://www.mdpi.com/1999-4923/13/5/622

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