Non-Specific Inhibition of Dipeptidyl Peptidases 8/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation

Non-Specific Inhibition of Dipeptidyl Peptidases 8/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation

DPP4 may play a relevant role in MSC differentiation into osteoblasts or adipocytes. Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4i), such as sitagliptin and vildagliptin, are used as antidiabetic drugs. However, vildagliptin is not a specific DPP4i and also inhibits DPP8/9, which is involved in en...

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Bibliographic Details
Main Authors: Bárbara Torrecillas-Baena, Marta Camacho-Cardenosa, José Manuel Quesada-Gómez, Paloma Moreno-Moreno, Gabriel Dorado, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Journal of Clinical Medicine
Subjects:
DPP4
DPP8/9
vildagliptin
sitagliptin
1G244
human mesenchymal stem cells
Online Access:https://www.mdpi.com/2077-0383/12/14/4632

Internet

https://www.mdpi.com/2077-0383/12/14/4632

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