Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats

Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats

Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biod...

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Bibliographic Details
Main Authors: Leandro Francisco Silva Bastos, Juliana Priscila Vago, Thaís Rolla Caux, Bruna Lopes Costa, Adriana Martins Godin, Raquel Rezende Menezes, Roberta Ribas Pena, Armando Silva-Cunha, Lirlândia Pires Sousa, Renes Resende Machado, Márcio Flávio Dutra Moraes, Sílvia Ligório Fialho, Márcio Matos Coelho
Format: Article
Language:English
Published: Universidade de São Paulo 2019-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Chronic Constriction Injury
Dexamethasone/ pharmacology
Delivery device
Neuropathic Pain/ chemically induced
Nuclear Factor kappa B/ drug effects
Neuralgia/ chemically induced
NF-kappa B/ drug effects
Sciatic Nerve/ injuries
Absorbable Implants/ trends
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100591&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100591&tlng=en

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