IL‐34 deficiency impairs FOXP3+ Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis

IL‐34 deficiency impairs FOXP3+ Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis

Background Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL‐34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its expression by CD8+ Tregs in a rat model of transplan...

Full description

Bibliographic Details
Main Authors: Antoine Freuchet, Apolline Salama, Séverine Bézie, Laurent Tesson, Séverine Rémy, Romain Humeau, Hadrien Règue, Céline Sérazin, Léa Flippe, Pärt Peterson, Nadège Vimond, Claire Usal, Séverine Ménoret, Jean‐Marie Heslan, Franck Duteille, Frédéric Blanchard, Magali Giral, Marco Colonna, Ignacio Anegon, Carole Guillonneau
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Clinical and Translational Medicine
Subjects:
autoimmunity
CRISPR/Cas9
Foxp3
IL‐34
immunotherapy
knockout
Online Access:https://doi.org/10.1002/ctm2.988

Internet

https://doi.org/10.1002/ctm2.988

Similar Items