Improved endurance capacity of diabetic mice during SGLT2 inhibition: Role of AICARP, an AMPK activator in the soleus

Improved endurance capacity of diabetic mice during SGLT2 inhibition: Role of AICARP, an AMPK activator in the soleus

Abstract Background Diabetes is associated with an increased risk of deleterious changes in muscle mass and function or sarcopenia, leading to physical inactivity and worsening glycaemic control. Given the negative energy balance during sodium–glucose cotransporter‐2 (SGLT2) inhibition, whether SGLT...

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Bibliographic Details
Main Authors: Shintaro Nakamura, Yasutaka Miyachi, Akihito Shinjo, Hisashi Yokomizo, Masatomo Takahashi, Kohta Nakatani, Yoshihiro Izumi, Hiroko Otsuka, Naoichi Sato, Ryuichi Sakamoto, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
AICARP
AMPK
endurance exercise
fatty acid oxidation
SGLT2 inhibitor
skeletal muscle
Online Access:https://doi.org/10.1002/jcsm.13350

Internet

https://doi.org/10.1002/jcsm.13350

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