Rbfox1 Is Expressed in the Mouse Brain in the Form of Multiple Transcript Variants and Contains Functional E Boxes in Its Alternative Promoters

Rbfox1 Is Expressed in the Mouse Brain in the Form of Multiple Transcript Variants and Contains Functional E Boxes in Its Alternative Promoters

The RNA-binding protein RBFOX1 is an important regulator of neuron development and neuronal excitability. Rbfox1 is a dosage-sensitive gene and in both mice and humans, decreased expression of Rbfox1 has been linked to neurodevelopmental disorders. Alternative promoters drive expression of Rbfox1 tr...

Full description

Bibliographic Details
Main Authors: Sonia Casanovas, Laura Schlichtholz, Sophia Mühlbauer, Sri Dewi, Martin Schüle, Dennis Strand, Susanne Strand, Lea Zografidou, Jennifer Winter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Rbfox1
alternative splicing
neurodevelopmental disorders
autism
alternative promoters
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00066/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00066/full

Similar Items