Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

Abstract Borrelia burgdorferi, the tick-transmitted spirochete agent of Lyme disease, has a highly segmented genome with a linear chromosome and various linear or circular plasmids. Here, by imaging several chromosomal loci and 16 distinct plasmids, we show that B. burgdorferi is polyploid during gr...

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Bibliographic Details
Main Authors: Constantin N. Takacs, Jenny Wachter, Yingjie Xiang, Zhongqing Ren, Xheni Karaboja, Molly Scott, Matthew R. Stoner, Irnov Irnov, Nicholas Jannetty, Patricia A. Rosa, Xindan Wang, Christine Jacobs-Wagner
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34876-4

Internet

https://doi.org/10.1038/s41467-022-34876-4

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