GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells

GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells

GJB2 gene (that encodes Cx26) mutations are causal of hearing loss highlighting the importance of Cx26-based channel signaling amongst the supporting cells in the organ of Corti. While the majority of these GJB2 mutations are inherited in an autosomal recessive manner, others are inherited in an aut...

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Bibliographic Details
Main Authors: Rianne Beach, Julia M. Abitbol, Brian L. Allman, Jessica L. Esseltine, Qing Shao, Dale W. Laird
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
GJB2
hearing loss
Cx26
cochlear cells
mutants
disease
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00215/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00215/full

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