Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots

Abstract While blood clot formation has been relatively well studied, little is known about the mechanisms underlying the subsequent structural and mechanical clot remodeling called contraction or retraction. Impairment of the clot contraction process is associated with both life-threatening bleedin...

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Bibliographic Details
Main Authors: Christian Michael, Francesco Pancaldi, Samuel Britton, Oleg V. Kim, Alina D. Peshkova, Khoi Vo, Zhiliang Xu, Rustem I. Litvinov, John W. Weisel, Mark Alber
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05240-z