A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function

A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function

To maintain energy homeostasis despite variable energy supply and consumption along the diurnal cycle, the liver relies on a circadian clock synchronized to food timing. Perturbed feeding and fasting cycles have been associated with clock disruption and metabolic diseases; however, the mechanisms ar...

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Bibliographic Details
Main Authors: Aurore Woller, Hélène Duez, Bart Staels, Marc Lefranc
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
mammalian circadian clock
metabolism
mathematical model
SIRT1
AMPK
NAMPT
NAD+
REV-ERB
metabolic disorders
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631316X

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http://www.sciencedirect.com/science/article/pii/S221112471631316X

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