NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

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Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immunity or the microbiota cause disease. We previousl...

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Bibliographic Details
Main Authors: Sergey S. Seregin, Natasha Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A. Pudlo, Jonathan Mitchell, Nielson T. Baxter, Lili Zhao, Patrick D. Schloss, Eric C. Martens, Kathryn A. Eaton, Grace Y. Chen
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
Microbiota
colitis
Akkermansia
IL-10
NLRP6
NLRs
intestine
inflammation
dysbiosis
pathobiont
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304576

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http://www.sciencedirect.com/science/article/pii/S2211124717304576

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