Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion o...

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Bibliographic Details
Main Authors: Taha Azad, Ragunath Singaravelu, Mathieu J.F. Crupi, Taylor Jamieson, Jaahnavi Dave, Emily E.F. Brown, Reza Rezaei, Zaid Taha, Stephen Boulton, Nikolas T. Martin, Abera Surendran, Joanna Poutou, Mina Ghahremani, Kazem Nouri, Jack T. Whelan, Jessie Duong, Sarah Tucker, Jean-Simon Diallo, John C. Bell, Carolina S. Ilkow
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Membranes
Subjects:
trimerization
spike protein
receptor-binding domain
transmembrane domain
SARS-CoV-2
vaccine development
Online Access:https://www.mdpi.com/2077-0375/10/9/215

Internet

https://www.mdpi.com/2077-0375/10/9/215

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