Identification of linoleic acid as an antithrombotic component of Wenxin Keli via selective inhibition of p-selectin-mediated platelet activation

Identification of linoleic acid as an antithrombotic component of Wenxin Keli via selective inhibition of p-selectin-mediated platelet activation

Atrial fibrillation significantly increases the risk of thromboembolism and stroke. Wenxin Keli (WXKL) is a widely used Chinese patent medicine against arrhythmia but if it has antithrombotic activity is unknown. Since platelet activation is a critical factor in thrombosis and the key target for man...

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Bibliographic Details
Main Authors: Qianqian Tao, Guangxu Xiao, Taiyi Wang, Lei Zhang, Mingxing Yu, Li Peng, Linhong Han, Xiaoli Du, Wenrun Han, Shuang He, Ming Lyu, Yan Zhu
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Wenxin Keli
Systems pharmacology
Linoleic acid
Platelet activation
Thrombosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222008423

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http://www.sciencedirect.com/science/article/pii/S0753332222008423

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