Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport

Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport

The amyloid precursor protein (APP) is a key molecular component of Alzheimer’s disease (AD) pathogenesis. Proteolytic APP processing generates various cleavage products, including extracellular amyloid beta (Aβ) and the cytoplasmic APP intracellular domain (AICD). Although the role of AICD in the a...

Full description

Bibliographic Details
Main Authors: Svenja König, Nadine Schmidt, Karin Bechberger, Sarah Morris, Mercedes Priego, Hannah Zaky, Yuyu Song, Jan Pielage, Silke Brunholz, Scott T. Brady, Stefan Kins, Gerardo Morfini
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
Alzheimer’s disease
APP
AICD
kinases
NPTY
Online Access:https://www.mdpi.com/2073-4409/12/19/2403

Internet

https://www.mdpi.com/2073-4409/12/19/2403

Similar Items