Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway

Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway

A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor synthesis and T- and B-lymphocyte activation are 3 hallmarks of rheumatoid arthritis (RA) pathology. Interleukin-6 (IL-6), IL-7, IL-17, IL-12/IL-23 and growth factors, granulocyte macrophage-colony stimulating...

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Bibliographic Details
Main Author: Charles J. Malemud
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Pharmaceuticals
Subjects:
arthritis
autoimmune
Janus kinase
signal transducers and activators of transcription
small molecule inhibitor
Online Access:http://www.mdpi.com/1424-8247/3/5/1446/

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http://www.mdpi.com/1424-8247/3/5/1446/

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