Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies

Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies

Molecular screening tools have significantly eased the assessment of potential germline susceptibility factors that may underlie the development of pediatric malignancies. Most of the hitherto published studies utilize the comparative analyses of the respective patients' germline and tumor tiss...

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Bibliographic Details
Main Authors: Triantafyllia Brozou, Layal Yasin, Danielle Brandes, Daniel Picard, Carolin Walter, Julian Varghese, Martin Dugas, Ute Fischer, Arndt Borkhardt, Oskar A. Haas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pediatrics
Subjects:
pediatric hematological malignancies
trio-whole-exome sequencing
cancer predisposition syndrome
inheritance pattern
de novo mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.1080347/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2022.1080347/full

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