Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level

Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level

BackgroundThe interplay between bacterial virulence factors and the host innate immune response in pneumococcal meningitis (PM) can result in uncontrolled neuroinflammation, which is known to induce apoptotic death of progenitor cells and post-mitotic neurons in the hippocampal dentate gyrus, result...

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Bibliographic Details
Main Authors: Larissa Marcely Gomes Cassiano, Marina da Silva Oliveira, Karina Barbosa de Queiroz, Alice Muglia Thomaz da Silva Amancio, Anna Christina de Matos Salim, Gabriel da Rocha Fernandes, Cláudia Martins Carneiro, Roney Santos Coimbra
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
pneumococcal meningitis
vitamin B12
epidrugs
neuroinflammation
histone methylation
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250055/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250055/full

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