Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding

Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding

Abstract Background We aimed to develop a publicly shared computational physiologically based pharmacokinetic (PBPK) model to reliably simulate and analyze radiopharmaceutical therapies (RPTs), including probing of hot-cold ligand competitions as well as alternative injection scenarios and drug desi...

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Bibliographic Details
Main Authors: Ali Fele-Paranj, Babak Saboury, Carlos Uribe, Arman Rahmim
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
PBPK modeling
Radiopharmaceutical therapy
Theranostics
Computational modeling
Therapy optimization
Online Access:https://doi.org/10.1186/s41181-023-00236-w

Internet

https://doi.org/10.1186/s41181-023-00236-w

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