Biomimetic Silica Particles with Self-Loading BMP-2 Knuckle Epitope Peptide and Its Delivery for Bone Regeneration

Biomimetic Silica Particles with Self-Loading BMP-2 Knuckle Epitope Peptide and Its Delivery for Bone Regeneration

Biomimetic silica deposition is an in-situ immobilization method for bioactive molecules under biocompatible conditions. The osteoinductive P4 peptide derived from the knuckle epitope of bone morphogenetic protein (BMP), which binds to BMP receptor-II (BMPRII), has been newly found to contain silica...

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Bibliographic Details
Main Authors: Mi-Ran Ki, Thi Khoa My Nguyen, Tae-In Park, Hae-Min Park, Seung Pil Pack
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
BMP2
BMP2 knuckle epitope residues
P4 peptide
biomimetic silica deposition
drug delivery
controlled release
Online Access:https://www.mdpi.com/1999-4923/15/4/1061

Internet

https://www.mdpi.com/1999-4923/15/4/1061

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