ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation

ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation

Abstract Background ROR2 is a tyrosine-kinase receptor whose expression is dysregulated in many human diseases. In cancer, ROR2 stimulates proliferation, survival, migration, and metastasis, and is associated with more aggressive tumor stages. The purpose of this work is to study the role of ROR2 in...

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Bibliographic Details
Main Authors: María Victoria Castro, Gastón Alexis Barbero, Paula Máscolo, Rocío Ramos, María Josefina Quezada, Pablo Lopez-Bergami
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
ROR2
ERK
Melanoma
Chemoresistance
Apoptosis
Online Access:https://doi.org/10.1186/s11658-022-00327-7

Internet

https://doi.org/10.1186/s11658-022-00327-7

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