A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs
Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistan...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/3/47 |
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| author | Takanori Eguchi Eman Ahmed Taha Stuart K. Calderwood Kisho Ono |
| author_facet | Takanori Eguchi Eman Ahmed Taha Stuart K. Calderwood Kisho Ono |
| author_sort | Takanori Eguchi |
| collection | DOAJ |
| description | Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing drug resistance phenotype is often coupled with cellular dedifferentiation and transformation in cells undergoing epithelial-mesenchymal transition (EMT), and the adoption of a cancer stem cell phenotype. The release of EVs is also involved in immunosuppression. Herein, we address different aspects by which EVs modulate the tumor microenvironment to become resistant to anticancer and antibody-based drugs, as well as the concept of the resistance-associated secretory phenotype (RASP). |
| first_indexed | 2024-03-12T04:16:03Z |
| format | Article |
| id | doaj.art-6718e770e714459c96b12a8e64ed362a |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T04:16:03Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-6718e770e714459c96b12a8e64ed362a2023-09-03T10:38:59ZengMDPI AGBiology2079-77372020-03-01934710.3390/biology9030047biology9030047A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based DrugsTakanori Eguchi0Eman Ahmed Taha1Stuart K. Calderwood2Kisho Ono3Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USADepartment of Oral and Maxillofacial Surgery, Okayama University Hospital, Okayama 700-0914, JapanExtracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing drug resistance phenotype is often coupled with cellular dedifferentiation and transformation in cells undergoing epithelial-mesenchymal transition (EMT), and the adoption of a cancer stem cell phenotype. The release of EVs is also involved in immunosuppression. Herein, we address different aspects by which EVs modulate the tumor microenvironment to become resistant to anticancer and antibody-based drugs, as well as the concept of the resistance-associated secretory phenotype (RASP).https://www.mdpi.com/2079-7737/9/3/47extracellular vesicle (ev)exosomeoncosomedrug resistanceepithelial-mesenchymal transition (emt)heat shock protein (hsp)cell stress responseresistance-associated secretory phenotype (rasp)hypoxiaacidosistumor immunology |
| spellingShingle | Takanori Eguchi Eman Ahmed Taha Stuart K. Calderwood Kisho Ono A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs Biology extracellular vesicle (ev) exosome oncosome drug resistance epithelial-mesenchymal transition (emt) heat shock protein (hsp) cell stress response resistance-associated secretory phenotype (rasp) hypoxia acidosis tumor immunology |
| title | A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs |
| title_full | A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs |
| title_fullStr | A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs |
| title_full_unstemmed | A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs |
| title_short | A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs |
| title_sort | novel model of cancer drug resistance oncosomal release of cytotoxic and antibody based drugs |
| topic | extracellular vesicle (ev) exosome oncosome drug resistance epithelial-mesenchymal transition (emt) heat shock protein (hsp) cell stress response resistance-associated secretory phenotype (rasp) hypoxia acidosis tumor immunology |
| url | https://www.mdpi.com/2079-7737/9/3/47 |
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