Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3

Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3

Objective: Hepatic insulin resistance, which leads to increased hepatic gluconeogenesis, is a major contributor to fasting hyperglycemia in type 2 diabetes mellitus (T2DM). However, the mechanism of impaired insulin-dependent suppression of hepatic gluconeogenesis remains elusive. Delta/Notch-like e...

Full description

Bibliographic Details
Main Authors: Junfeng Li, Yan Huang, Xinyu Yang, Yuli Cai, Ye Wang, Wenling Dai, Liu Jiang, Changhua Wang, Zhongyuan Wen
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Molecular Metabolism
Subjects:
DNER
TRB3
Ubiquitin-proteasome system
Gluconeogenesis
Insulin resistance
Type 2 diabetes mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000589

Internet

http://www.sciencedirect.com/science/article/pii/S2212877824000589

Similar Items