Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer

Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer

Primary prostate cancer (PC) progresses to castration-resistant PC (CRPC) under androgen deprivation therapy, by mechanisms e.g. expression of androgen receptor (AR) splice variant-7 (AR-V7). Here we conducted comprehensive epigenome and transcriptome analyses comparing LNCaP, primary PC cells, and...

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Bibliographic Details
Main Authors: Masahiro Sugiura, Hiroaki Sato, Atsushi Okabe, Masaki Fukuyo, Yasunobu Mano, Ken-ichi Shinohara, Bahityar Rahmutulla, Kosuke Higuchi, Maihulan Maimaiti, Manato Kanesaka, Yusuke Imamura, Tomomi Furihata, Shinichi Sakamoto, Akira Komiya, Naohiko Anzai, Yoshikatsu Kanai, Jun Luo, Tomohiko Ichikawa, Atsushi Kaneda
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Translational Oncology
Subjects:
Castration-resistant prostate cancer (CRPC)
Androgen receptor (AR)
AR-V7
NUP210
SLC3A2
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320304071

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http://www.sciencedirect.com/science/article/pii/S1936523320304071

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