Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model. Advanced glycation end-products (AGEs), an important pathogenic factor of DCM, were found to induc...

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Bibliographic Details
Main Authors: Xiang Wang, Xinxin Chen, Wenqian Zhou, Hongbo Men, Terigen Bao, Yike Sun, Quanwei Wang, Yi Tan, Bradley B. Keller, Qian Tong, Yang Zheng, Lu Cai
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Advanced glycation end-products
AMPK
Cell death
Diabetic cardiomyopathy
Engineered cardiac tissue
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100397X

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http://www.sciencedirect.com/science/article/pii/S221138352100397X

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