Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity

Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity

Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown, recovery, and integrity of endothelial junctions.

Bibliographic Details
Main Authors: Eoin McEvoy, Tal Sneh, Emad Moeendarbary, Yousef Javanmardi, Nadia Efimova, Changsong Yang, Gloria E. Marino-Bravante, Xingyu Chen, Jorge Escribano, Fabian Spill, José Manuel Garcia-Aznar, Ashani T. Weeraratna, Tatyana M. Svitkina, Roger D. Kamm, Vivek B. Shenoy
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34701-y

Internet

https://doi.org/10.1038/s41467-022-34701-y

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