Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
Abstract The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disrupti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-05645-y |
| _version_ | 1797863399941472256 |
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| author | Mingyue Tan Yunfei Yin Xiao Ma Jun Zhang Wanqian Pan Minghao Tan Yongjian Zhao Tianke Yang Tingbo Jiang Hongxia Li |
| author_facet | Mingyue Tan Yunfei Yin Xiao Ma Jun Zhang Wanqian Pan Minghao Tan Yongjian Zhao Tianke Yang Tingbo Jiang Hongxia Li |
| author_sort | Mingyue Tan |
| collection | DOAJ |
| description | Abstract The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury. Meanwhile, a newly proposed type of cell death, ferroptosis, has been demonstrated to be closely related to the GSH system, which affects the process and outcome of myocardial injury. Moreover, in facing various pathological challenges, the mammalian heart, which possesses high levels of mitochondria and weak antioxidant capacity, is susceptible to oxidant production and oxidative damage. Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy. In this review, we first systematically describe the physiological functions and anabolism of the GSH system, as well as its effects on cardiac injury. Then, we discuss the relationship between the GSH system and ferroptosis in myocardial injury. Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches. |
| first_indexed | 2024-04-09T22:34:58Z |
| format | Article |
| id | doaj.art-671fef317b064cc2adc9d686c0d1b90c |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-09T22:34:58Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-671fef317b064cc2adc9d686c0d1b90c2023-03-22T12:32:51ZengNature Publishing GroupCell Death and Disease2041-48892023-02-0114211910.1038/s41419-023-05645-yGlutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosisMingyue Tan0Yunfei Yin1Xiao Ma2Jun Zhang3Wanqian Pan4Minghao Tan5Yongjian Zhao6Tianke Yang7Tingbo Jiang8Hongxia Li9Department of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Nursing, Tianfu College, Southwestern University of Finance and EconomicsDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan UniversityDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityDepartment of Cardiology, The First Affiliated Hospital of Soochow UniversityAbstract The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury. Meanwhile, a newly proposed type of cell death, ferroptosis, has been demonstrated to be closely related to the GSH system, which affects the process and outcome of myocardial injury. Moreover, in facing various pathological challenges, the mammalian heart, which possesses high levels of mitochondria and weak antioxidant capacity, is susceptible to oxidant production and oxidative damage. Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy. In this review, we first systematically describe the physiological functions and anabolism of the GSH system, as well as its effects on cardiac injury. Then, we discuss the relationship between the GSH system and ferroptosis in myocardial injury. Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches.https://doi.org/10.1038/s41419-023-05645-y |
| spellingShingle | Mingyue Tan Yunfei Yin Xiao Ma Jun Zhang Wanqian Pan Minghao Tan Yongjian Zhao Tianke Yang Tingbo Jiang Hongxia Li Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Cell Death and Disease |
| title | Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis |
| title_full | Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis |
| title_fullStr | Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis |
| title_full_unstemmed | Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis |
| title_short | Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis |
| title_sort | glutathione system enhancement for cardiac protection pharmacological options against oxidative stress and ferroptosis |
| url | https://doi.org/10.1038/s41419-023-05645-y |
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