Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation

Background and aim: Overdose of acetaminophen (APAP) leads to liver injury, which is one of the most common causes of liver failure in the United States. We previously demonstrated that pharmacological activation of autophagy protects against APAP-induced liver injury in mice via removal of damaged...

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Bibliographic Details
Main Authors: Yuan Li, Hong-Min Ni, Hartmut Jaeschke, Wen-Xing Ding
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-03-01
Series:Liver Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568418300321