Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and has become a public health concern worldwide. The hallmark of NAFLD is hepatic steatosis. Therefore, there is an urgent need to develop new therapeutic strategies that are efficacious and have...

Full description

Bibliographic Details
Main Authors: Dan Feng, Jun Zou, Dongfang Su, Haiyan Mai, Shanshan Zhang, Peiyang Li, Xiumei Zheng
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Nutrition & Metabolism
Subjects:
Hepatic steatosis
Curcumin
Tight junction protein
Lipopolysaccharide
Toll like receptor 4
Nuclear factor-κB
Online Access:http://link.springer.com/article/10.1186/s12986-019-0410-3

Internet

http://link.springer.com/article/10.1186/s12986-019-0410-3

Similar Items