Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and has become a public health concern worldwide. The hallmark of NAFLD is hepatic steatosis. Therefore, there is an urgent need to develop new therapeutic strategies that are efficacious and have...

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Bibliographic Details
Main Authors: Dan Feng, Jun Zou, Dongfang Su, Haiyan Mai, Shanshan Zhang, Peiyang Li, Xiumei Zheng
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Nutrition & Metabolism
Subjects:
Hepatic steatosis
Curcumin
Tight junction protein
Lipopolysaccharide
Toll like receptor 4
Nuclear factor-κB
Online Access:http://link.springer.com/article/10.1186/s12986-019-0410-3

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