Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein.

Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein.

Human tyrosinase (hTyr) is a Type 1 membrane bound glycoenzyme that catalyzes the initial and rate-limiting steps of melanin production in the melanosome. Mutations in the Tyr gene are linked to oculocutaneous albinism type 1 (OCA1), an autosomal recessive disorder. Currently, the application of enz...

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Bibliographic Details
Main Authors: Nicole J Kus, Monika B Dolinska, Kenneth L Young, Emilios K Dimitriadis, Paul T Wingfield, Yuri V Sergeev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198247/1/pone.0198247.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T143149Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=3ac872929e897bb10ad1df834d903da8febdfaa3268a2dcd8e35fa1c506b5746d5263c56058a058f3af3cedb08dfb58c24e17d4e9502f5f7aefd290686d8d19054e4b15b24d5d92dc90ddae5a8dd8b9d1f9d3f135ba282ee3ba6a0c51bd3a0b425eed333cca8d68977497cce538a47f2ae00a70a9d96eda1ace3fdbd420cec33872291d897cc13bc0cced0f50dc7f46fa3607f40c2470980957685458afbd4e97056012370a75132dd06a330643c77523b96e36c8d6061380bb7e39057fa05a7e3514858605dd74c414620ae1ebe312342b19d2f4c58d5a77527db36925ec0989fb74fb9d4153f5afae3b522313bba203e3c71e0da3d135f6598123102c822b9

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