Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

The retinal ganglion cells of the optic nerve have a limited capacity for self-repair after injury. Valproate is a histone deacetylase inhibitor and multitarget drug, which has been demonstrated to protect retinal neurons. In this study, we established rat models of optic nerve-crush injury and inje...

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Bibliographic Details
Main Authors: Feng Pan, Dan Hu, Li-Juan Sun, Qian Bai, Yu-Sheng Wang, Xu Hou
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; c/ebp homologous protein; caspase-12; endoplasmic reticulum; glucose-regulated protein 78; optic nerve crush; phosphorylated eukaryotic translation initiation factor 2α; retinal ganglion cells; unfolded protein response; valproate
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1607;epage=1612;aulast=Pan

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1607;epage=1612;aulast=Pan

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