Melatonin Prevents UVB-Induced Skin Photoaging by Inhibiting Oxidative Damage and MMP Expression through JNK/AP-1 Signaling Pathway in Human Dermal Fibroblasts

Melatonin Prevents UVB-Induced Skin Photoaging by Inhibiting Oxidative Damage and MMP Expression through JNK/AP-1 Signaling Pathway in Human Dermal Fibroblasts

Exposure to ultraviolet (UV) irradiation causes damage to the skin and induces photoaging. UV irradiation stimulates production of reactive oxygen/nitrogen species, which results in activation of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinases (MAPK) in fibroblasts. MAP...

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Bibliographic Details
Main Authors: Mehtap Yuksel Egrilmez, Semra Kocturk, Sebnem Aktan, Gulgun Oktay, Halil Resmi, Hatice Simsek Keskin, Gul Guner Akdogan, Sebnem Ozkan
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Life
Subjects:
ultraviolet B
melatonin
oxidative damage
JNK pathway
activator protein-1
matrix metalloproteinase
Online Access:https://www.mdpi.com/2075-1729/12/7/950

Internet

https://www.mdpi.com/2075-1729/12/7/950

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