Conformational dynamics promotes disordered regions from function-dispensable to essential in evolved site-specific DNA recombinases

Conformational dynamics promotes disordered regions from function-dispensable to essential in evolved site-specific DNA recombinases

Protein intrinsically disordered regions (IDRs) play pivotal roles in molecular recognition and regulatory processes through structural disorder-to-order transitions. To understand and exploit the distinctive functional implications of IDRs and to unravel the underlying molecular mechanisms, structu...

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Bibliographic Details
Main Authors: Carla Guillén-Pingarrón, Pedro M. Guillem-Gloria, Anjali Soni, Gloria Ruiz-Gómez, Martina Augsburg, Frank Buchholz, Massimiliano Anselmi, M. Teresa Pisabarro
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Intrinsically disordered protein regions
site-specific DNA recombinase
Evolution
Molecular dynamics
Structural disorder
Thermodynamic stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000174

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http://www.sciencedirect.com/science/article/pii/S2001037022000174

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