Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos

Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos

During the first lineage segregation, mammalian embryos generate the inner cell mass (ICM) and trophectoderm (TE). ICM gives rise to the epiblast (EPI) that forms all cell types of the body, an ability referred to as pluripotency. The molecular mechanisms that induce pluripotency in embryos remain i...

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Bibliographic Details
Main Authors: Yanlin Hou, Zhengwen Nie, Qi Jiang, Sergiy Velychko, Sandra Heising, Ivan Bedzhov, Guangming Wu, Kenjiro Adachi, Hans R Scholer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
embryonic development
inner cell mass
chromatin accessibility
transcriptome
Oct4
Sox2
Online Access:https://elifesciences.org/articles/100735

Internet

https://elifesciences.org/articles/100735

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