Insight on ecDNA-mediated tumorigenesis and drug resistance

Insight on ecDNA-mediated tumorigenesis and drug resistance

Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements. Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility, leading to tumorigenesis and malignant development....

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Bibliographic Details
Main Authors: Qing Huang, Su Zhang, Guosong Wang, Junhong Han
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
ecDNA
Tumor evolution
Oncogene amplification
Intratumoral heterogeneity
Cancer therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024037642

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http://www.sciencedirect.com/science/article/pii/S2405844024037642

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