The Role of V-Domain Ig Suppressor of T Cell Activation (VISTA) in Cancer Therapy: Lessons Learned and the Road Ahead

The Role of V-Domain Ig Suppressor of T Cell Activation (VISTA) in Cancer Therapy: Lessons Learned and the Road Ahead

Immune checkpoints (ICs) have pivotal roles in regulating immune responses. The inhibitory ICs in the tumor microenvironment (TME) have been implicated in the immune evasion of tumoral cells. Therefore, identifying and targeting these inhibitory ICs might be critical for eliminating tumoral cells. V...

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Bibliographic Details
Main Authors: Negar Hosseinkhani, Afshin Derakhshani, Mahdi Abdoli Shadbad, Antonella Argentiero, Vito Racanelli, Tohid Kazemi, Ahad Mokhtarzadeh, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
VISTA
immune checkpoints
cancer
immunotherapy
immune-resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.676181/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.676181/full

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