Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

Abstract Background Mutations in the telomerase reverse transcriptase (TERT) promoter region have been proposed as novel mechanisms for the transcriptional activation of telomerase. Two recurrent mutations in the TERT promoter, C228T and C250T, are prognostic biomarkers. Herein, we directly compared...

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Bibliographic Details
Main Authors: So Young Kang, Deok Geun Kim, Hyunjin Kim, Yoon Ah Cho, Sang Yun Ha, Ghee Young Kwon, Kee-Taek Jang, Kyoung-Mee Kim
Format: Article
Language:English
Published: BMC 2022-02-01
Series:BMC Medical Genomics
Subjects:
TERT promoter mutation
PCR
Next-generation sequencing
Comparison
Online Access:https://doi.org/10.1186/s12920-022-01175-2

Internet

https://doi.org/10.1186/s12920-022-01175-2

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