Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis

Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis

Abstract Background Recent studies of cortical pathology in secondary progressive multiple sclerosis have shown that a more severe clinical course and the presence of extended subpial grey matter lesions with significant neuronal/glial loss and microglial activation are associated with meningeal inf...

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Bibliographic Details
Main Authors: Roberta Magliozzi, Owain William Howell, Pascal Durrenberger, Eleonora Aricò, Rachel James, Carolina Cruciani, Cheryl Reeves, Federico Roncaroli, Richard Nicholas, Richard Reynolds
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
TNF
Meningeal inflammation
Cortical grey matter lesion
Necroptosis
Online Access:https://doi.org/10.1186/s12974-019-1650-x

Internet

https://doi.org/10.1186/s12974-019-1650-x

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