Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against <i>Yersinia pestis</i> Infection in a Bubonic Plague Model

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against <i>Yersinia pestis</i> Infection in a Bubonic Plague Model

Plague is a zoonotic disease that is caused by <i>Yersinia pestis</i>. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by <i>Y. pestis</i>, can passively protect mice from plague. An analysis of protective mAbs that bind to V-antig...

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Bibliographic Details
Main Authors: Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Antibodies
Subjects:
monoclonal antibodies
<i>Yersinia pestis</i>
plague
binding sites
avidities
affinities
Online Access:https://www.mdpi.com/2073-4468/9/3/37

Internet

https://www.mdpi.com/2073-4468/9/3/37

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