Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3

Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by a CAG repeat expansion in the ATXN3 gene. Though the ATXN3 protein is expressed ubiquitously throughout the CNS, regional pathology in SCA3 patients is observed within select neuronal populations and more recently within o...

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Bibliographic Details
Main Authors: Kristen H. Schuster, Danielle M. DiFranco, Alexandra F. Putka, Juan P. Mato, Sabrina I. Jarrah, Nicholas R. Stec, Vikram O. Sundararajan, Hayley S. McLoughlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neuroscience
Subjects:
Machado-Joseph disease
polyglutamine (polyQ) diseases
myelination
MJD
SCA3
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1118429/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1118429/full

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