Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S]

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S]

Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance. We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a sterile 20 protein kinase reported to be upstream...

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Bibliographic Details
Main Authors: Laura V. Danai, Adilson Guilherme, Kalyani V. Guntur, Juerg Straubhaar, Sarah M. Nicoloro, Michael P. Czech
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Journal of Lipid Research
Subjects:
lipid synthesis
insulin
mitogen-activated protein kinase kinase kinase kinase 4
sterol-regulated element binding protein-1
c-Jun NH2-terminal kinase
mechanistic target of rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352962

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http://www.sciencedirect.com/science/article/pii/S0022227520352962

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