Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis

Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis

Abstract Background Animal studies reporting immune checkpoint inhibitors (CPIs) improved host defense and survival during bacterial sepsis provided one basis for phase I CPI sepsis trials. We performed a systematic review and meta-analysis examining the benefit of CPI therapy in preclinical studies...

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Bibliographic Details
Main Authors: Lindsay M. Busch, Junfeng Sun, Xizhong Cui, Peter Q. Eichacker, Parizad Torabi-Parizi
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:Intensive Care Medicine Experimental
Subjects:
Checkpoint molecule
Checkpoint inhibitor
Sepsis
Preclinical model
Bacterial infection
Treatment
Online Access:https://doi.org/10.1186/s40635-019-0290-x

Internet

https://doi.org/10.1186/s40635-019-0290-x

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