Low-Affinity NMDA Receptor Antagonist Hemantane in a Topical Formulation Attenuates Arthritis Induced by Freund’s Complete Adjuvant in Rats

Purpose: N-methyl-D-aspartate (NMDA) receptors that are expressed by T-cells modulate T-cell proliferation, cytotoxicity and cell migration toward chemokines. Several studies have shown an anti-inflammatory effect of NMDA receptor antagonists. This study compares the effect of the noncompetitive low...

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Bibliographic Details
Main Authors: Elena Ivanova, Alexander Matyushkin, Alexandra Sorokina, Svetlana Alexeeva, Irina Miroshkina, Kirill Kachalov, Tatyana Voronina, Andrey Durnev
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-14-241.pdf