Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease

Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease

Objective: Mitochondria fuel most animal cells with ATP, ensuring proper energetic metabolism of organs. Early and extensive mitochondrial dysfunction often leads to severe disorders through multiorgan failure. Hacd2 gene encodes an enzyme involved in very long chain fatty acid (C ≥ 18) synthesis, y...

Full description

Bibliographic Details
Main Authors: Nahed Khadhraoui, Alexandre Prola, Aymeline Vandestienne, Jordan Blondelle, Laurent Guillaud, Guillaume Courtin, Maxime Bodak, Bastien Prost, Hélène Huet, Mélody Wintrebert, Christine Péchoux, Audrey Solgadi, Frédéric Relaix, Laurent Tiret, Fanny Pilot-Storck
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Metabolism
Subjects:
Phospholipid
Fatty acid
VLCFA
ELOVL
OXPHOS coupling
Heart development
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782300011X

Internet

http://www.sciencedirect.com/science/article/pii/S221287782300011X

Similar Items