Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis

Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis

Abstract Background Spinal cord injury (SCI) brings a heavy burden to individuals and society, and there is no effective treatment at present. Exosomes (EX) are cell secreted vesicles containing molecules such as nucleic acids and proteins, which hold promise for the treatment of SCI. Netrin-1 is an...

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Bibliographic Details
Main Authors: Xiao Lu, Guangyu Xu, Zhidi Lin, Fei Zou, Siyang Liu, Yuxuan Zhang, Wei Fu, Jianyuan Jiang, Xiaosheng Ma, Jian Song
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-01-01
Series:Biomaterials Research
Subjects:
Engineered exosomes
Netrin-1
modRNA
Spinal cord injury
Unc5b/PI3K/AKT/mTOR
Online Access:https://doi.org/10.1186/s40824-023-00339-0

Internet

https://doi.org/10.1186/s40824-023-00339-0

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